This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1gx5
From Proteopedia
(New page: 200px<br /> <applet load="1gx5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gx5, resolution 1.70Å" /> '''HEPATITIS C VIRUS R...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GX5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Hepatitis_c_virus_genotype_1b_(isolate_bk) Hepatitis c virus genotype 1b (isolate bk)]] with MN and GTP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GX5 OCA]]. | + | 1GX5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Hepatitis_c_virus_genotype_1b_(isolate_bk) Hepatitis c virus genotype 1b (isolate bk)]] with MN and GTP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Structure known Active Site: C. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GX5 OCA]]. |
==Reference== | ==Reference== | ||
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides., Bressanelli S, Tomei L, Rey FA, De Francesco R, J Virol. 2002 Apr;76(7):3482-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11884572 11884572] | Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides., Bressanelli S, Tomei L, Rey FA, De Francesco R, J Virol. 2002 Apr;76(7):3482-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11884572 11884572] | ||
[[Category: Hepatitis c virus genotype 1b (isolate bk)]] | [[Category: Hepatitis c virus genotype 1b (isolate bk)]] | ||
| + | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bressanelli, S.]] | [[Category: Bressanelli, S.]] | ||
| Line 30: | Line 31: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:57:54 2007'' |
Revision as of 09:53, 30 October 2007
|
HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH GTP AND MANGANESE
Overview
We report here the results of a systematic high-resolution X-ray, crystallographic analysis of complexes of the hepatitis C virus (HCV) RNA, polymerase with ribonucleoside triphosphates (rNTPs) and divalent metal, ions. An unexpected observation revealed by this study is the existence of, a specific rGTP binding site in a shallow pocket at the molecular surface, of the enzyme, 30 A away from the catalytic site. This previously, unidentified rGTP pocket, which lies at the interface between fingers and, thumb, may be an allosteric regulatory site and could play a role in, allowing alternative interactions between the two domains during a, possible conformational change of the enzyme required for efficient, initiation. The electron density map at 1.7-A resolution clearly shows the, mode of ... [(full description)]
About this Structure
1GX5 is a [Single protein] structure of sequence from [Hepatitis c virus genotype 1b (isolate bk)] with MN and GTP as [ligands]. Active as [RNA-directed RNA polymerase], with EC number [2.7.7.48]. Structure known Active Site: C. Full crystallographic information is available from [OCA].
Reference
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides., Bressanelli S, Tomei L, Rey FA, De Francesco R, J Virol. 2002 Apr;76(7):3482-92. PMID:11884572
Page seeded by OCA on Tue Oct 30 11:57:54 2007
Categories: Hepatitis c virus genotype 1b (isolate bk) | RNA-directed RNA polymerase | Single protein | Bressanelli, S. | Rey, F.A. | GTP | MN | Atp binding | Coat protein | Core protein | Envelope protein | Glycoprotein | Helicase | Nonstructural protein | Polyprotein | Rna-directed rna polymerase | Transferase | Transmembrane
