1xpa
From Proteopedia
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| - | [[Image:1xpa. | + | [[Image:1xpa.jpg|left|200px]]<br /><applet load="1xpa" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1xpa" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1xpa" /> | caption="1xpa" /> | ||
'''SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE'''<br /> | '''SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XPA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 1XPA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=NUL:Zn Binding Site'>NUL</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XPA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:39:46 2007'' |
Revision as of 16:29, 18 December 2007
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SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Contents |
Overview
The solution structure of the central domain of the human nucleotide, excision repair protein XPA, which binds to damaged DNA and replication, protein A (RPA), was determined by nuclear magnetic resonance (NMR), spectroscopy. The central domain consists of a zinc-containing subdomain, and a C-terminal subdomain. The zinc-containing subdomain has a compact, globular structure and is distinct from the zinc-fingers found in, transcription factors. The C-terminal subdomain folds into a novel, alpha/beta structure with a positively charged superficial cleft. From the, NMR spectra of the complexes, DNA and RPA binding surfaces are suggested.
Disease
Known diseases associated with this structure: Xeroderma pigmentosum, group A OMIM:[611153]
About this Structure
1XPA is a Single protein structure of sequence from Homo sapiens with ZN as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA., Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M, Nat Struct Biol. 1998 Aug;5(8):701-6. PMID:9699634
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