1u6q

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[[Image:1u6q.jpg|left|200px]]
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{{STRUCTURE_1u6q| PDB=1u6q | SCENE= }}
{{STRUCTURE_1u6q| PDB=1u6q | SCENE= }}
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'''Substituted 2-Naphthamadine inhibitors of Urokinase'''
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===Substituted 2-Naphthamadine inhibitors of Urokinase===
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==Overview==
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A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 15582418 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15582418}}
==Disease==
==Disease==
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[[Category: Wendt, M D.]]
[[Category: Wendt, M D.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:49:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:32:51 2008''

Revision as of 12:32, 28 July 2008

Template:STRUCTURE 1u6q

Contents

Substituted 2-Naphthamadine inhibitors of Urokinase

Template:ABSTRACT PUBMED 15582418

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

1U6Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties., Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL, Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. PMID:15582418

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