1u76

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[[Image:1u76.gif|left|200px]]
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{{STRUCTURE_1u76| PDB=1u76 | SCENE= }}
{{STRUCTURE_1u76| PDB=1u76 | SCENE= }}
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'''Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit'''
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===Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit===
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==Overview==
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Human Proliferating Cellular Nuclear Antigen (hPCNA), a member of the sliding clamp family of proteins, makes specific protein-protein interactions with DNA replication and repair proteins through a small peptide motif termed the PCNA-interacting protein, or PIP-box. We solved the structure of hPCNA bound to PIP-box-containing peptides from the p66 subunit of the human replicative DNA polymerase-delta (452-466) at 2.6 A and of the flap endonuclease (FEN1) (331-350) at 1.85 A resolution. Both structures demonstrate that the pol-delta p66 and FEN1 peptides interact with hPCNA at the same site shown to bind the cdk-inhibitor p21(CIP1). Binding studies indicate that peptides from the p66 subunit of the pol-delta holoenzyme and FEN1 bind hPCNA from 189- to 725-fold less tightly than those of p21. Thus, the PIP-box and flanking regions provide a small docking peptide whose affinities can be readily adjusted in accord with biological necessity to mediate the binding of DNA replication and repair proteins to hPCNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15576034 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15576034}}
==About this Structure==
==About this Structure==
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[[Category: Pip-box]]
[[Category: Pip-box]]
[[Category: Sliding clamp]]
[[Category: Sliding clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:50:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:44:17 2008''

Revision as of 05:44, 29 July 2008

Image:1u76.png

Template:STRUCTURE 1u76

Crystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit

Template:ABSTRACT PUBMED 15576034

About this Structure

1U76 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1., Bruning JB, Shamoo Y, Structure. 2004 Dec;12(12):2209-19. PMID:15576034

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