1u7b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1u7b.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1u7b.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1u7b| PDB=1u7b | SCENE= }}
{{STRUCTURE_1u7b| PDB=1u7b | SCENE= }}
-
'''Crystal structure of hPCNA bound to residues 331-350 of the flap endonuclease-1 (FEN1)'''
+
===Crystal structure of hPCNA bound to residues 331-350 of the flap endonuclease-1 (FEN1)===
-
==Overview==
+
<!--
-
Human Proliferating Cellular Nuclear Antigen (hPCNA), a member of the sliding clamp family of proteins, makes specific protein-protein interactions with DNA replication and repair proteins through a small peptide motif termed the PCNA-interacting protein, or PIP-box. We solved the structure of hPCNA bound to PIP-box-containing peptides from the p66 subunit of the human replicative DNA polymerase-delta (452-466) at 2.6 A and of the flap endonuclease (FEN1) (331-350) at 1.85 A resolution. Both structures demonstrate that the pol-delta p66 and FEN1 peptides interact with hPCNA at the same site shown to bind the cdk-inhibitor p21(CIP1). Binding studies indicate that peptides from the p66 subunit of the pol-delta holoenzyme and FEN1 bind hPCNA from 189- to 725-fold less tightly than those of p21. Thus, the PIP-box and flanking regions provide a small docking peptide whose affinities can be readily adjusted in accord with biological necessity to mediate the binding of DNA replication and repair proteins to hPCNA.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15576034}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15576034 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15576034}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Pip-box]]
[[Category: Pip-box]]
[[Category: Sliding clamp]]
[[Category: Sliding clamp]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:50:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:03:53 2008''

Revision as of 17:03, 28 July 2008

Image:1u7b.png

Template:STRUCTURE 1u7b

Crystal structure of hPCNA bound to residues 331-350 of the flap endonuclease-1 (FEN1)

Template:ABSTRACT PUBMED 15576034

About this Structure

1U7B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1., Bruning JB, Shamoo Y, Structure. 2004 Dec;12(12):2209-19. PMID:15576034

Page seeded by OCA on Mon Jul 28 20:03:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u7b"
Personal tools