This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1u89

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1u89.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1u89.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1u89| PDB=1u89 | SCENE= }}
{{STRUCTURE_1u89| PDB=1u89 | SCENE= }}
-
'''Solution structure of VBS2 fragment of talin'''
+
===Solution structure of VBS2 fragment of talin===
-
==Overview==
+
<!--
-
The cytoskeletal protein talin plays a key role in activating integrins and in coupling them to the actin cytoskeleton. Its N-terminal globular head, which binds beta integrins, is linked to an extended rod having a C-terminal actin binding site and several vinculin binding sites (VBSs). The NMR structure of residues 755-889 of the rod (containing a VBS) is shown to be an amphipathic four-helix bundle with a left-handed topology. A talin peptide corresponding to the VBS binds the vinculin head; the X-ray crystallographic structure of this complex shows that the residues which interact with vinculin are buried in the hydrophobic core of the talin fragment. NMR shows that the interaction involves a major structural change in the talin fragment, including unfolding of one of its helices, making the VBS accessible to vinculin. Interestingly, the talin 755-889 fragment binds more than one vinculin head molecule, suggesting that the talin rod may contain additional as yet unrecognized VBSs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15642262}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15642262 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15642262}}
==About this Structure==
==About this Structure==
-
1U89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U89 OCA].
+
1U89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U89 OCA].
==Reference==
==Reference==
Line 32: Line 36:
[[Category: 4-helix bundle]]
[[Category: 4-helix bundle]]
[[Category: Left-handed]]
[[Category: Left-handed]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:53:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:09:32 2008''

Revision as of 23:09, 27 July 2008

Image:1u89.png

Template:STRUCTURE 1u89

Solution structure of VBS2 fragment of talin

Template:ABSTRACT PUBMED 15642262

About this Structure

1U89 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head., Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL, Structure. 2005 Jan;13(1):65-74. PMID:15642262

Page seeded by OCA on Mon Jul 28 02:09:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u89"
Personal tools