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1u96

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[[Image:1u96.jpg|left|200px]]
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{{STRUCTURE_1u96| PDB=1u96 | SCENE= }}
{{STRUCTURE_1u96| PDB=1u96 | SCENE= }}
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'''Solution Structure of Yeast Cox17 with Copper Bound'''
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===Solution Structure of Yeast Cox17 with Copper Bound===
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==Overview==
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Cox17 is a 69-residue cysteine-rich, copper-binding protein that has been implicated in the delivery of copper to the Cu(A) and Cu(B) centers of cytochrome c oxidase via the copper-binding proteins Sco1 and Cox11, respectively. According to isothermal titration calorimetry experiments, fully reduced Cox17 binds one Cu(I) ion with a K(a) of (6.15 +/- 5.83) x 10(6) M(-1). The solution structures of both apo and Cu(I)-loaded Cox17 reveal two alpha helices preceded by an extensive, unstructured N-terminal region. This region is reminiscent of intrinsically unfolded proteins. The two structures are very similar overall with residues in the copper-binding region becoming more ordered in Cu(I)-loaded Cox17. Based on the NMR data, the Cu(I) ion has been modeled as two-coordinate with ligation by conserved residues Cys(23) and Cys(26). This site is similar to those observed for the Atx1 family of copper chaperones and is consistent with reported mutagenesis studies. A number of conserved, positively charged residues may interact with complementary surfaces on Sco1 and Cox11, facilitating docking and copper transfer. Taken together, these data suggest that Cox17 is not only well suited to a copper chaperone function but is specifically designed to interact with two different target proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 15465825 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15465825}}
==About this Structure==
==About this Structure==
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1U96 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U96 OCA].
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1U96 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U96 OCA].
==Reference==
==Reference==
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[[Category: Two alpha-helice]]
[[Category: Two alpha-helice]]
[[Category: Unstructured n-terminus]]
[[Category: Unstructured n-terminus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:55:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:59:26 2008''

Revision as of 15:59, 27 July 2008

Image:1u96.png

Template:STRUCTURE 1u96

Solution Structure of Yeast Cox17 with Copper Bound

Template:ABSTRACT PUBMED 15465825

About this Structure

1U96 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Yeast cox17 solution structure and Copper(I) binding., Abajian C, Yatsunyk LA, Ramirez BE, Rosenzweig AC, J Biol Chem. 2004 Dec 17;279(51):53584-92. Epub 2004 Oct 1. PMID:15465825

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