1u9k

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[[Image:1u9k.jpg|left|200px]]
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{{Seed}}
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[[Image:1u9k.png|left|200px]]
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{{STRUCTURE_1u9k| PDB=1u9k | SCENE= }}
{{STRUCTURE_1u9k| PDB=1u9k | SCENE= }}
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'''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76'''
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===Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76===
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==Overview==
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Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.
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The line below this paragraph, {{ABSTRACT_PUBMED_15561137}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15561137 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15561137}}
==About this Structure==
==About this Structure==
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[[Category: Innate immunity]]
[[Category: Innate immunity]]
[[Category: Trem-1]]
[[Category: Trem-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:56:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:43:35 2008''

Revision as of 00:43, 28 July 2008

Image:1u9k.png

Template:STRUCTURE 1u9k

Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76

Template:ABSTRACT PUBMED 15561137

About this Structure

1U9K is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A., Kelker MS, Debler EW, Wilson IA, J Mol Biol. 2004 Dec 10;344(5):1175-81. PMID:15561137

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