9ea7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The Structure of ApoB100 from Human Low-Density Lipoprotein== |
| - | + | <StructureSection load='9ea7' size='340' side='right'caption='[[9ea7]], [[Resolution|resolution]] 9.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ea7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EA7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ea7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ea7 OCA], [https://pdbe.org/9ea7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ea7 RCSB], [https://www.ebi.ac.uk/pdbsum/9ea7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ea7 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Berndsen | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/APOB_HUMAN APOB_HUMAN] Homozygous familial hypercholesterolemia. The disease is caused by variants affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products (PubMed:21981844).<ref>PMID:21981844</ref> The disease is caused by variants affecting the gene represented in this entry. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APOB_HUMAN APOB_HUMAN] Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Berndsen ZT]] | ||
| + | [[Category: Cassidy CK]] | ||
Current revision
The Structure of ApoB100 from Human Low-Density Lipoprotein
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