9hb7

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m (Protected "9hb7" [edit=sysop:move=sysop])
Current revision (06:50, 16 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hb7 is ON HOLD until Paper Publication
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==Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128==
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<StructureSection load='9hb7' size='340' side='right'caption='[[9hb7]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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Authors: Schuetz, A., Gogolin, A., Pfeifer, J., Mallow, K., Nazare, M., Specker, E., Heinemann, U.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HB7 FirstGlance]. <br>
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Description: Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9551876&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=JCR:8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione'>JCR</scene></td></tr>
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[[Category: Nazare, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hb7 OCA], [https://pdbe.org/9hb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hb7 RCSB], [https://www.ebi.ac.uk/pdbsum/9hb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hb7 ProSAT]</span></td></tr>
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[[Category: Mallow, K]]
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</table>
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[[Category: Heinemann, U]]
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== Disease ==
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[[Category: Pfeifer, J]]
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[https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
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[[Category: Specker, E]]
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== Function ==
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[[Category: Schuetz, A]]
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[https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN]
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[[Category: Gogolin, A]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gogolin A]]
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[[Category: Heinemann U]]
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[[Category: Mallow K]]
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[[Category: Nazare M]]
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[[Category: Pfeifer J]]
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[[Category: Schuetz A]]
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[[Category: Specker E]]

Current revision

Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128

PDB ID 9hb7

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OCA

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