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1ubd

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{{STRUCTURE_1ubd| PDB=1ubd | SCENE= }}
{{STRUCTURE_1ubd| PDB=1ubd | SCENE= }}
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'''CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT'''
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===CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT===
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==Overview==
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Ying-Yang 1 protein (YY1) supports specific, unidirectional initiation of messenger RNA production by RNA polymerase II from two adjacent start sites in the adeno-associated virus P5 promoter, a process which is independent of the TATA box-binding protein (TBP). The 2.5-A resolution YY1-initiator element cocrystal structure reveals four zinc fingers recognizing a YY1-binding consensus sequence. Upstream of the transcription start sites protein-DNA contacts involve both strands and downstream they are virtually restricted to the template strand, permitting access to the active center of RNA polymerase II and ensuring specificity and directionality. The observed pattern of protein-DNA contacts also explains YY1 binding to a preformed transcription bubble, and YY1 binding to a DNA/RNA hybrid analog of the P5 promoter region containing a nascent RNA transcript. A model is proposed for YY1-directed, TBP-independent transcription initiation.
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(as it appears on PubMed at http://www.pubmed.gov), where 8942976 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8942976}}
==About this Structure==
==About this Structure==
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[[Category: Yy1]]
[[Category: Yy1]]
[[Category: Zinc finger protein]]
[[Category: Zinc finger protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:59:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:01:02 2008''

Revision as of 10:01, 27 July 2008

Image:1ubd.png

Template:STRUCTURE 1ubd

CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT

Template:ABSTRACT PUBMED 8942976

About this Structure

1UBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator., Houbaviy HB, Usheva A, Shenk T, Burley SK, Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13577-82. PMID:8942976

Page seeded by OCA on Sun Jul 27 13:01:02 2008

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