1xuo
From Proteopedia
(New page: 200px<br /> <applet load="1xuo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xuo, resolution 1.80Å" /> '''X-ray structure of ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1xuo. | + | [[Image:1xuo.jpg|left|200px]]<br /><applet load="1xuo" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1xuo" size=" | + | |
caption="1xuo, resolution 1.80Å" /> | caption="1xuo, resolution 1.80Å" /> | ||
'''X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution'''<br /> | '''X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1XUO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and LA1 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1XUO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=LA1:'>LA1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUO OCA]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 28: | ||
[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:10:34 2008'' |
Revision as of 15:10, 15 February 2008
|
X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution
Overview
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1, inhibitors. The synthesis, structure, and biological evaluation of these, 1,4-diazepine-2,5-diones and related derivatives are described.
About this Structure
1XUO is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1., Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G, Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. PMID:15686945
Page seeded by OCA on Fri Feb 15 17:10:34 2008
Categories: Homo sapiens | Single protein | Albert, R. | Ehrhardt, C. | Guo, Q. | Hommel, U. | Kallen, J. | Myers, S. | Sabio, M. | Wattanasin, S. | Weckbecker, G. | Welzenbach, K. | LA1 | MG | I-domain | Integrin
