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1uc7

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{{STRUCTURE_1uc7| PDB=1uc7 | SCENE= }}
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'''Crystal structure of DsbDgamma'''
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===Crystal structure of DsbDgamma===
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==Overview==
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The Escherichia coli transmembrane protein DsbD transfers electrons from the cytoplasm to the periplasm through a cascade of thiol-disulfide exchange reactions. In this process, the C-terminal periplasmic domain of DsbD (DsbDgamma) shuttles the reducing potential from the membrane domain (DsbDbeta) to the N-terminal periplasmic domain (DsbDalpha). The crystal structure of DsbDgamma determined at 1.9 A resolution reveals that the domain has a thioredoxin fold with an extended N-terminal stretch. In comparison to thioredoxin, the DsbDgamma structure exhibits the stabilized active site conformation and the extended active site alpha2 helix that explain the domain's substrate specificity and the redox potential shift, respectively. The hypothetical model of the DsbDgamma:DsbDalpha complex based on the DsbDgamma structure and previous structural studies indicates that the conserved hydrophobic residue in the C-X-X-C motif of DsbDgamma may be important in the specific recognition of DsbDalpha.
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(as it appears on PubMed at http://www.pubmed.gov), where 12753926 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12753926}}
==About this Structure==
==About this Structure==
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[[Category: Son, J H.]]
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[[Category: Thioredoxin-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:31:59 2008''

Revision as of 16:32, 28 July 2008

Image:1uc7.png

Template:STRUCTURE 1uc7

Crystal structure of DsbDgamma

Template:ABSTRACT PUBMED 12753926

About this Structure

1UC7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of DsbDgamma reveals the mechanism of redox potential shift and substrate specificity(1)., Kim JH, Kim SJ, Jeong DG, Son JH, Ryu SE, FEBS Lett. 2003 May 22;543(1-3):164-9. PMID:12753926

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