1ucf

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{{STRUCTURE_1ucf| PDB=1ucf | SCENE= }}
{{STRUCTURE_1ucf| PDB=1ucf | SCENE= }}
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'''The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease'''
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===The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease===
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==Overview==
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DJ-1 is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 is related to male fertility, and its level in sperm decreases in response to exposure to sperm toxicants. DJ-1 has also been identified as a hydroperoxide-responsive protein. Recently, a mutation of DJ-1 was found to be responsible for familial Parkinson's disease. Here, we present the crystal structure of DJ-1 refined to 1.95-A resolution. DJ-1 forms a dimer in the crystal, and the monomer takes a flavodoxin-like Rossmann-fold. DJ-1 is structurally most similar to the monomer subunit of protease I, the intracellular cysteine protease from Pyrococcus horikoshii, and belongs to the Class I glutamine amidotransferase-like superfamily. However, DJ-1 contains an additional alpha-helix at the C-terminal region, which blocks the putative catalytic site of DJ-1 and appears to regulate the enzymatic activity. DJ-1 may induce conformational changes to acquire catalytic activity in response to oxidative stress.
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==About this Structure==
==About this Structure==
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[[Category: Taira, T.]]
[[Category: Taira, T.]]
[[Category: Flavodoxin-like rossmann fold]]
[[Category: Flavodoxin-like rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:02:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:19:27 2008''

Revision as of 12:19, 29 July 2008

Image:1ucf.png

Template:STRUCTURE 1ucf

The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease

Template:ABSTRACT PUBMED 12796482

About this Structure

1UCF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease., Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F, J Biol Chem. 2003 Aug 15;278(33):31380-4. Epub 2003 Jun 8. PMID:12796482

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