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1uhx

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{{STRUCTURE_1uhx| PDB=1uhx | SCENE= }}
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'''Crystal structure of d(GCGAGAGC): the base-intercalated duplex'''
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===Crystal structure of d(GCGAGAGC): the base-intercalated duplex===
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==Overview==
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DNA fragments containing the sequence d(GCGAAAGC) prefer to adopt a base-intercalated (zipper-like) duplex in the crystalline state. To investigate effects of point mutation at the 5th residue on the structure, two crystal structures of d(GCGAGAGC) and d(GCGATAGC) have been determined by X-ray crystallography. In the respective crystals, the two octamers related by a crystallographic two-fold symmetry are aligned in an anti-parallel fashion and associated to each other to form a duplex, suggesting that the base-intercalated duplex is stable even when the 5th residue is mutated with other bases. The sheared G3:A6 pair formation makes the two phosphate backbones closer and facilitates formation of the A-X*-X-A* base-intercalated motif. The three duplexes are assembled around the three-fold axis, and their 3rd and 4th residues are bound to the hexamine cobalt chloride. The central 5th residues are bound to another cation.
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(as it appears on PubMed at http://www.pubmed.gov), where 14646150 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14646150}}
==About this Structure==
==About this Structure==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Sheared g:a pair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:15:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:43:57 2008''

Revision as of 01:43, 29 July 2008

Image:1uhx.png

Template:STRUCTURE 1uhx

Crystal structure of d(GCGAGAGC): the base-intercalated duplex

Template:ABSTRACT PUBMED 14646150

About this Structure

Full crystallographic information is available from OCA.

Reference

X-ray analyses of d(GCGAXAGC) containing G and T at X: the base-intercalated duplex is still stable even in point mutants at the fifth residue., Kondo J, Umeda S, Fujita K, Sunami T, Takenaka A, J Synchrotron Radiat. 2004 Jan 1;11(Pt 1):117-20. Epub 2003 Nov 28. PMID:14646150

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