We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1ukl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ukl.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ukl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ukl| PDB=1ukl | SCENE= }}
{{STRUCTURE_1ukl| PDB=1ukl | SCENE= }}
-
'''Crystal structure of Importin-beta and SREBP-2 complex'''
+
===Crystal structure of Importin-beta and SREBP-2 complex===
-
==Overview==
+
<!--
-
The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through a direct interaction of its helix-loop-helix leucine zipper domain with importin-beta. We show the crystal structure of importin-beta complexed with the active form of SREBP-2. Importin-beta uses characteristic long helices like a pair of chopsticks to interact with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a pseudo-twofold symmetry on its surface structure so that it can accommodate a symmetric dimer molecule. Importin-beta may use a similar strategy to recognize other dimeric cargoes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14645851}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14645851 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14645851}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Nuclear transport factor]]
[[Category: Nuclear transport factor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:21:24 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:44:30 2008''

Revision as of 10:44, 29 July 2008

Image:1ukl.png

Template:STRUCTURE 1ukl

Crystal structure of Importin-beta and SREBP-2 complex

Template:ABSTRACT PUBMED 14645851

About this Structure

1UKL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor., Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y, Science. 2003 Nov 28;302(5650):1571-5. PMID:14645851

Page seeded by OCA on Tue Jul 29 13:44:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ukl"
Personal tools