1ul5

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{{STRUCTURE_1ul5| PDB=1ul5 | SCENE= }}
{{STRUCTURE_1ul5| PDB=1ul5 | SCENE= }}
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'''Solution structure of the DNA-binding domain of squamosa promoter binding protein-like 7'''
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===Solution structure of the DNA-binding domain of squamosa promoter binding protein-like 7===
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==Overview==
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SQUAMOSA promoter binding proteins (SBPs) form a major family of plant-specific transcription factors related to flower development. Although SBPs are heterogeneous in primary structure, they share a highly conserved DNA-binding domain (DBD) that has been suggested to be zinc binding. Here we report the NMR solution structures of DBDs of two SBPs of Arabidopsis thaliana, SPL4 and SPL7. The two share essentially the same structural features. Each structure contains two zinc-binding sites consisting of eight Cys or His residues in a Cys3HisCys2HisCys or Cys6HisCys sequence motif in which the first four residues coordinate to one zinc and the last four coordinate to the other. These structures are dissimilar to other known zinc-binding structures, and thus represent a novel type of zinc-binding motif. The electrostatic profile on the surface suggested that a continuous region, including all the conserved basic residues, is involved in the DNA binding, the mode of which is likely to be novel as well.
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{{ABSTRACT_PUBMED_15001351}}
==About this Structure==
==About this Structure==
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1UL5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL5 OCA].
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1UL5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL5 OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:22:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:23:23 2008''

Revision as of 13:23, 28 July 2008

Image:1ul5.png

Template:STRUCTURE 1ul5

Solution structure of the DNA-binding domain of squamosa promoter binding protein-like 7

Template:ABSTRACT PUBMED 15001351

About this Structure

1UL5 is a Single protein structure of sequence from Arabidopsis thaliana. Full experimental information is available from OCA.

Reference

A novel zinc-binding motif revealed by solution structures of DNA-binding domains of Arabidopsis SBP-family transcription factors., Yamasaki K, Kigawa T, Inoue M, Tateno M, Yamasaki T, Yabuki T, Aoki M, Seki E, Matsuda T, Nunokawa E, Ishizuka Y, Terada T, Shirouzu M, Osanai T, Tanaka A, Seki M, Shinozaki K, Yokoyama S, J Mol Biol. 2004 Mar 12;337(1):49-63. PMID:15001351

Page seeded by OCA on Mon Jul 28 16:23:23 2008

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