1ula

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{{STRUCTURE_1ula| PDB=1ula | SCENE= }}
{{STRUCTURE_1ula| PDB=1ula | SCENE= }}
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'''APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS'''
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===APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS===
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==Overview==
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Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one that utilized interactive computer graphics, Monte Carlo-based conformational searching, energy minimization, and x-ray crystallography. The proposed compounds were synthesized and tested by an in vitro assay. Among the compounds designed and synthesized are the most potent competitive inhibitors of purine nucleoside phosphorylase thus far reported.
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(as it appears on PubMed at http://www.pubmed.gov), where 1763067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1763067}}
==About this Structure==
==About this Structure==
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[[Category: Stoeckler, J D.]]
[[Category: Stoeckler, J D.]]
[[Category: Pentosyltransferase]]
[[Category: Pentosyltransferase]]
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Revision as of 17:02, 27 July 2008

Image:1ula.png

Template:STRUCTURE 1ula

APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS

Template:ABSTRACT PUBMED 1763067

About this Structure

1ULA is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2pnp. Full crystallographic information is available from OCA.

Reference

Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors., Ealick SE, Babu YS, Bugg CE, Erion MD, Guida WC, Montgomery JA, Secrist JA 3rd, Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11540-4. PMID:1763067

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