This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ulb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ulb.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ulb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ulb| PDB=1ulb | SCENE= }}
{{STRUCTURE_1ulb| PDB=1ulb | SCENE= }}
-
'''APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS'''
+
===APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS===
-
==Overview==
+
<!--
-
Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one that utilized interactive computer graphics, Monte Carlo-based conformational searching, energy minimization, and x-ray crystallography. The proposed compounds were synthesized and tested by an in vitro assay. Among the compounds designed and synthesized are the most potent competitive inhibitors of purine nucleoside phosphorylase thus far reported.
+
The line below this paragraph, {{ABSTRACT_PUBMED_1763067}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 1763067 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_1763067}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Stoeckler, J D.]]
[[Category: Stoeckler, J D.]]
[[Category: Pentosyltransferase]]
[[Category: Pentosyltransferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:22:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:56:41 2008''

Revision as of 17:56, 28 July 2008

Image:1ulb.png

Template:STRUCTURE 1ulb

APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS

Template:ABSTRACT PUBMED 1763067

About this Structure

1ULB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors., Ealick SE, Babu YS, Bugg CE, Erion MD, Guida WC, Montgomery JA, Secrist JA 3rd, Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11540-4. PMID:1763067

Page seeded by OCA on Mon Jul 28 20:56:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ulb"
Personal tools