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1um8

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[[Image:1um8.jpg|left|200px]]
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{{STRUCTURE_1um8| PDB=1um8 | SCENE= }}
{{STRUCTURE_1um8| PDB=1um8 | SCENE= }}
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'''Crystal structure of helicobacter pylori ClpX'''
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===Crystal structure of helicobacter pylori ClpX===
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==Overview==
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ClpX, a heat shock protein 100 chaperone, which acts as the regulatory subunit of the ATP-dependent ClpXP protease, is responsible for intracellular protein remodeling and degradation. To provide a structural basis for a better understanding of the function of the Clp ATPase family, the crystal structures of Helicobacter pylori ClpX, lacking an N-terminal Cys cluster region complexed with ADP, was determined. The overall structure of ClpX is similar to that of heat shock locus U (HslU), consisting of two subdomains, with ADP bound at the subdomain interface. The crystal structure of ClpX reveals that a conserved tripeptide (LGF) is located on the tip of ClpP binding loop extending from the N-terminal subdomain. A hexameric model of ClpX suggests that six tripeptides make hydrophobic contacts with the hydrophobic clefts of the ClpP heptmer asymmetrically. In addition, the nucleotide binding environment provides the structural explanation for the hexameric assembly and the modulation of ATPase activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_14514695}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14514695 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14514695}}
==About this Structure==
==About this Structure==
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[[Category: Kim, K K.]]
[[Category: Kim, K K.]]
[[Category: Clpp binding loop]]
[[Category: Clpp binding loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:25:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:38:36 2008''

Revision as of 09:38, 29 July 2008

Image:1um8.png

Template:STRUCTURE 1um8

Crystal structure of helicobacter pylori ClpX

Template:ABSTRACT PUBMED 14514695

About this Structure

1UM8 is a Single protein structure of sequence from Helicobacter pylori 26695. Full crystallographic information is available from OCA.

Reference

Crystal structure of ClpX molecular chaperone from Helicobacter pylori., Kim DY, Kim KK, J Biol Chem. 2003 Dec 12;278(50):50664-70. Epub 2003 Sep 26. PMID:14514695

Page seeded by OCA on Tue Jul 29 12:38:36 2008

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