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1umk

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[[Image:1umk.gif|left|200px]]
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{{STRUCTURE_1umk| PDB=1umk | SCENE= }}
{{STRUCTURE_1umk| PDB=1umk | SCENE= }}
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'''The Structure of Human Erythrocyte NADH-cytochrome b5 Reductase'''
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===The Structure of Human Erythrocyte NADH-cytochrome b5 Reductase===
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==Overview==
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Erythrocyte NADH-cytochrome b(5) reductase reduces methaemoglobin to functional haemoglobin. In order to examine the function of the enzyme, the structure of NADH-cytochrome b(5) reductase from human erythrocytes has been determined and refined by X-ray crystallography. At 1.75 A resolution, the root-mean-square deviations (r.m.s.d.) from standard bond lengths and angles are 0.006 A and 1.03 degrees , respectively. The molecular structure was compared with those of rat NADH-cytochrome b(5) reductase and corn nitrate reductase. The human reductase resembles the rat reductase in overall structure as well as in many side chains. Nevertheless, there is a large main-chain shift from the human reductase to the rat reductase or the corn reductase caused by a single-residue replacement from proline to threonine. A model of the complex between cytochrome b(5) and the human reductase has been built and compared with that of the haem-containing domain of the nitrate reductase molecule. The interaction between cytochrome b(5) and the human reductase differs from that of the nitrate reductase because of differences in the amino-acid sequences. The structures around 15 mutation sites of the human reductase have been examined for the influence of residue substitutions using the program ROTAMER. Five mutations in the FAD-binding domain seem to be related to cytochrome b(5).
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(as it appears on PubMed at http://www.pubmed.gov), where 15502298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15502298}}
==About this Structure==
==About this Structure==
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[[Category: Flavoprotein]]
[[Category: Flavoprotein]]
[[Category: Nadh-binding domain]]
[[Category: Nadh-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:25:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:42:25 2008''

Revision as of 20:42, 27 July 2008

Image:1umk.png

Template:STRUCTURE 1umk

The Structure of Human Erythrocyte NADH-cytochrome b5 Reductase

Template:ABSTRACT PUBMED 15502298

About this Structure

1UMK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human erythrocyte NADH-cytochrome b5 reductase., Bando S, Takano T, Yubisui T, Shirabe K, Takeshita M, Nakagawa A, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1929-34. Epub 2004, Oct 20. PMID:15502298

Page seeded by OCA on Sun Jul 27 23:42:25 2008

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