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1ump

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[[Image:1ump.gif|left|200px]]
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[[Image:1ump.png|left|200px]]
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==Overview==
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{{ABSTRACT_15113001}}
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The membrane protein squalene-hopene cyclase was cocrystallized with 2-azasqualene and analyzed by X-ray diffraction to 2.13 A resolution. The conformation of this close analog was clearly established, and it agreed with the common textbook presentation. The bound squalene undergoes only small conformational changes during the formation of rings A through D, thus requiring no intermediate. However, ring E formation is hindered by an entropic barrier, which may explain its absence in the steroids. The structure analysis revealed a mobile region between the active center cavity and the membrane, which may melt, opening a passage for squalene and hopene.
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==About this Structure==
==About this Structure==
1UMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMP OCA].
1UMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMP OCA].
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==Reference==
 
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Conversion of squalene to the pentacarbocyclic hopene., Reinert DJ, Balliano G, Schulz GE, Chem Biol. 2004 Jan;11(1):121-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15113001 15113001]
 
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Oxidosqualene cyclase]]
[[Category: Oxidosqualene cyclase]]
[[Category: Triterpene cyclase]]
[[Category: Triterpene cyclase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:26:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:03:34 2008''

Revision as of 15:03, 26 June 2008

Image:1ump.png

Template:STRUCTURE 1ump

GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE


Template:ABSTRACT 15113001

About this Structure

1UMP is a Single protein structure of sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:03:34 2008

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