9kna

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Current revision (06:22, 26 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9kna is ON HOLD until Paper Publication
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==NSD2-PWWP1 domain bound with compound 6==
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<StructureSection load='9kna' size='340' side='right'caption='[[9kna]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
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Authors: Huang, Y., Li, Y., Min, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9kna]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KNA FirstGlance]. <br>
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Description: NSD2-PWWP1 domain bound with compound 6
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Y3:~{N}-(4-AMINOPHENYL)-2-SELANYL-BENZAMIDE'>6Y3</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Min, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kna OCA], [https://pdbe.org/9kna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kna RCSB], [https://www.ebi.ac.uk/pdbsum/9kna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kna ProSAT]</span></td></tr>
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[[Category: Huang, Y]]
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</table>
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[[Category: Li, Y]]
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== Disease ==
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[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Wolf-Hirschhorn syndrome. A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH. WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
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== Function ==
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[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.<ref>PMID:11152655</ref> <ref>PMID:16115125</ref> <ref>PMID:18172012</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang Y]]
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[[Category: Li Y]]
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[[Category: Min J]]

Current revision

NSD2-PWWP1 domain bound with compound 6

PDB ID 9kna

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