GLP-1
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection size='340' side='right' scene='84/841095/Cv/1'> | <StructureSection size='340' side='right' scene='84/841095/Cv/1'> | ||
== Structure == | == Structure == | ||
| - | Bound to the GLP-1 receptor, GLP-1 has an <scene name='10/1067195/Glp1_only/1'>alpha-helical structure</scene> that is <scene name='10/1067195/Cv1/1'>bent</scene> near glycine in some complexes. In solution, GLP-1 is | + | Bound to the GLP-1 receptor, GLP-1 has an <scene name='10/1067195/Glp1_only/1'>alpha-helical structure</scene> that is <scene name='10/1067195/Cv1/1'>bent</scene> near glycine in some complexes. In solution, GLP-1 is <scene name='10/1067195/Glp-1_solution/1'>alpha-helical in its center</scene> according to NMR data. |
== Synthesis == | == Synthesis == | ||
Revision as of 03:58, 10 December 2024
Glucagon-like peptide 1 (GLP-1) is a hormone involved in insulin regulation. It was discovered when researchers found that glucose in the digestive tract led to higher insulin levels than the same amount of glucose administered directly in the blood stream. GLP-1 is produced in specialized cells in the intestine and in the pancreas, is released into the blood and has effects on cells in the pancreas, in the brain, and in many other organs. The half-life of GLP-1 is on the order of minutes, so it exerts a short-term effect unless continuously produced.
| |||||||||||
