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1unk

From Proteopedia

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[[Image:1unk.gif|left|200px]]
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{{STRUCTURE_1unk| PDB=1unk | SCENE= }}
{{STRUCTURE_1unk| PDB=1unk | SCENE= }}
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'''STRUCTURE OF COLICIN E7 IMMUNITY PROTEIN'''
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===STRUCTURE OF COLICIN E7 IMMUNITY PROTEIN===
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==Overview==
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Site-specific cleavage of mRNA has been identified in vivo for the polycistronic colicin E7 operon (ColE7), which occurs between G and A nucleotides located at the Asp52 codon (GAT) of the immunity gene (ceiE7). In vitro, this specific cleavage occurs only in the presence of the ceiE7 gene product (ImmE7). The crystal structure of dimeric ImmE7 has been determined at 1.8 A resolution by X-ray crystallographic analysis. We found that several residues located at the interface of dimeric ImmE7 bear surprising resemblance to the active sites of some RNases. These results suggest that dimeric ImmE7 may possess a novel RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream celE7 gene as well as degradation of the upstream ceaE7 mRNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 9135159 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9135159}}
==About this Structure==
==About this Structure==
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[[Category: Immunity protein]]
[[Category: Immunity protein]]
[[Category: Rnase active site]]
[[Category: Rnase active site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:28:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:50:52 2008''

Revision as of 06:50, 29 July 2008

Image:1unk.png

Template:STRUCTURE 1unk

STRUCTURE OF COLICIN E7 IMMUNITY PROTEIN

Template:ABSTRACT PUBMED 9135159

About this Structure

1UNK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A novel role of ImmE7 in the autoregulatory expression of the ColE7 operon and identification of possible RNase active sites in the crystal structure of dimeric ImmE7., Hsieh SY, Ko TP, Tseng MY, Ku W, Chak KF, Yuan HS, EMBO J. 1997 Mar 17;16(6):1444-54. PMID:9135159

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