1uot

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[[Image:1uot.gif|left|200px]]
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{{STRUCTURE_1uot| PDB=1uot | SCENE= }}
{{STRUCTURE_1uot| PDB=1uot | SCENE= }}
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'''HUMAN CD55 DOMAINS 3 & 4'''
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===HUMAN CD55 DOMAINS 3 & 4===
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==Overview==
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Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
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(as it appears on PubMed at http://www.pubmed.gov), where 12499389 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12499389}}
==About this Structure==
==About this Structure==
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[[Category: Immune system protein]]
[[Category: Immune system protein]]
[[Category: Ligand for cd97]]
[[Category: Ligand for cd97]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:30:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:39:47 2008''

Revision as of 21:39, 28 July 2008

Image:1uot.png

Template:STRUCTURE 1uot

HUMAN CD55 DOMAINS 3 & 4

Template:ABSTRACT PUBMED 12499389

About this Structure

1UOT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389

Page seeded by OCA on Tue Jul 29 00:39:47 2008

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