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1upk

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{{STRUCTURE_1upk| PDB=1upk | SCENE= }}
{{STRUCTURE_1upk| PDB=1upk | SCENE= }}
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'''CRYSTAL STRUCTURE OF MO25 IN COMPLEX WITH A C-TERMINAL PEPTIDE OF STRAD'''
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===CRYSTAL STRUCTURE OF MO25 IN COMPLEX WITH A C-TERMINAL PEPTIDE OF STRAD===
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==Overview==
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Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. The MO25 alpha crystal structure reveals a helical repeat fold, distantly related to the Armadillo proteins. A complex with the STRAD alpha peptide reveals a hydrophobic pocket that is involved in a unique and specific interaction with the Trp-Glu-Phe motif, further supported by mutagenesis studies. The data represent a first step toward structural analysis of the LKB1-STRAD-MO25 complex, and suggests that MO25 alpha is a scaffold protein to which other regions of STRAD-LKB1, cellular LKB1 substrates or regulatory components could bind.
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(as it appears on PubMed at http://www.pubmed.gov), where 14730349 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14730349}}
==About this Structure==
==About this Structure==
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[[Category: Ste-20 related adaptor]]
[[Category: Ste-20 related adaptor]]
[[Category: Strad]]
[[Category: Strad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:32:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:13:13 2008''

Revision as of 00:13, 28 July 2008

Image:1upk.png

Template:STRUCTURE 1upk

CRYSTAL STRUCTURE OF MO25 IN COMPLEX WITH A C-TERMINAL PEPTIDE OF STRAD

Template:ABSTRACT PUBMED 14730349

About this Structure

1UPK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor., Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM, Nat Struct Mol Biol. 2004 Feb;11(2):193-200. Epub 2004 Jan 18. PMID:14730349

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