1ya3
From Proteopedia
(New page: 200px<br /> <applet load="1ya3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ya3, resolution 2.34Å" /> '''Crystal structure o...) |
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| - | [[Image:1ya3.gif|left|200px]]<br /> | + | [[Image:1ya3.gif|left|200px]]<br /><applet load="1ya3" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ya3" size=" | + | |
caption="1ya3, resolution 2.34Å" /> | caption="1ya3, resolution 2.34Å" /> | ||
'''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension'''<br /> | '''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The S810L mutation within the human mineralocorticoid receptor (MR S810L) | + | The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with STR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1YA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=STR:'>STR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Huyet, J.]] | [[Category: Huyet, J.]] | ||
[[Category: Mayer, C.]] | [[Category: Mayer, C.]] | ||
| - | [[Category: Pinon, G | + | [[Category: Pinon, G M.]] |
| - | [[Category: Rafestin-Oblin, M | + | [[Category: Rafestin-Oblin, M E.]] |
[[Category: Rochel, M.]] | [[Category: Rochel, M.]] | ||
[[Category: STR]] | [[Category: STR]] | ||
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[[Category: steroid receptor]] | [[Category: steroid receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:03:13 2008'' |
Revision as of 14:03, 21 February 2008
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Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension
Contents |
Overview
The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
Disease
Known diseases associated with this structure: Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy OMIM:[600983], Pseudohypoaldosteronism type I, autosomal dominant OMIM:[600983]
About this Structure
1YA3 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension., Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME, Nat Struct Mol Biol. 2005 Jun;12(6):554-5. Epub 2005 May 22. PMID:15908963
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