1url

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{{STRUCTURE_1url| PDB=1url | SCENE= }}
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'''N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE'''
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===N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE===
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==Overview==
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Sialoadhesin is a sialic acid-binding immunoglobulin-like lectin (Siglec), expressed on subsets of macrophages. It is a model system for Siglec receptor-mediated cell surface interactions through binding of sialylated glycoconjugates. The N-terminal sialoadhesin domain can mediate sialic acid-binding on its own. The structure of this domain has been determined in complex with a sialic acid-containing heptapeptide, (Ala-Gly-His-Thr(Neu5Ac)-Trp-Gly-His). The affinity of sialoadhesin for this ligand is four times higher than the affinity for the natural linkage 2,3'-sialyllactose. The structure of the glycopeptide complex suggests strategies for ligand optimization and provides possible explanations for the observed differences in specificities among the Siglecs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15488769 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15488769}}
==About this Structure==
==About this Structure==
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[[Category: Oligosaccharide mimic]]
[[Category: Oligosaccharide mimic]]
[[Category: Sialoadhesin]]
[[Category: Sialoadhesin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:52:31 2008''

Revision as of 08:52, 28 July 2008

Image:1url.png

Template:STRUCTURE 1url

N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE

Template:ABSTRACT PUBMED 15488769

About this Structure

1URL is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Complex of sialoadhesin with a glycopeptide ligand., Bukrinsky JT, St Hilaire PM, Meldal M, Crocker PR, Henriksen A, Biochim Biophys Acta. 2004 Nov 1;1702(2):173-9. PMID:15488769

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