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9egk

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Current revision (05:48, 1 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9egk is ON HOLD until Paper Publication
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==E3 ubiquitin ligase HUWE1 homolog Tom1p in closed-conformation with internal Acidic Domain deletion==
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<StructureSection load='9egk' size='340' side='right'caption='[[9egk]], [[Resolution|resolution]] 3.07&Aring;' scene=''>
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Authors: Madrigal, J.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9egk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EGK FirstGlance]. <br>
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Description: E3 ubiquitin ligase HUWE1 homolog Tom1p in closed-conformation with internal Acidic Domain deletion
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.07&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9egk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9egk OCA], [https://pdbe.org/9egk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9egk RCSB], [https://www.ebi.ac.uk/pdbsum/9egk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9egk ProSAT]</span></td></tr>
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[[Category: Madrigal, J.M]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOM1_YEAST TOM1_YEAST] Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.<ref>PMID:10395901</ref> <ref>PMID:10660055</ref> <ref>PMID:10873801</ref> <ref>PMID:11238398</ref> <ref>PMID:9753545</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Madrigal JM]]

Current revision

E3 ubiquitin ligase HUWE1 homolog Tom1p in closed-conformation with internal Acidic Domain deletion

PDB ID 9egk

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