8pkn
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin== | |
| - | + | <StructureSection load='8pkn' size='340' side='right'caption='[[8pkn]], [[Resolution|resolution]] 2.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pkn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PKN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.26Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=117:7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-+3,5-DIHYDROXY-HEPTANOIC+ACID'>117</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pkn OCA], [https://pdbe.org/8pkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pkn RCSB], [https://www.ebi.ac.uk/pdbsum/8pkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pkn ProSAT]</span></td></tr> |
| - | [[Category: Manikandan | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Manikandan K]] | ||
| + | [[Category: Van Rooyen J]] | ||
Current revision
CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin
| |||||||||||
