9el1

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Current revision (10:58, 18 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9el1 is ON HOLD until Paper Publication
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==ML2-SA1/PI(3,5)P2 bound TRPML2 in an open state==
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<StructureSection load='9el1' size='340' side='right'caption='[[9el1]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9el1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EL1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BI6:(1~{R},2~{S},6~{S},7~{S})-5-[2,6-bis(chloranyl)phenyl]-3-oxa-4-azatricyclo[5.2.1.0^{2,6}]dec-4-ene'>A1BI6</scene>, <scene name='pdbligand=EUJ:[(2~{R})-2-octanoyloxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+octanoate'>EUJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9el1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9el1 OCA], [https://pdbe.org/9el1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9el1 RCSB], [https://www.ebi.ac.uk/pdbsum/9el1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9el1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCLN2_HUMAN MCLN2_HUMAN] Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840).[UniProtKB:Q8K595]<ref>PMID:17662026</ref> <ref>PMID:19885840</ref> <ref>PMID:19940139</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li X]]
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[[Category: Schmiege P]]

Current revision

ML2-SA1/PI(3,5)P2 bound TRPML2 in an open state

PDB ID 9el1

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