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1uun

From Proteopedia

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[[Image:1uun.jpg|left|200px]]
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{{STRUCTURE_1uun| PDB=1uun | SCENE= }}
{{STRUCTURE_1uun| PDB=1uun | SCENE= }}
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'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''
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===MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)===
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==Overview==
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Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.
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(as it appears on PubMed at http://www.pubmed.gov), where 14976314 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14976314}}
==About this Structure==
==About this Structure==
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[[Category: Mycobacteria]]
[[Category: Mycobacteria]]
[[Category: Porin]]
[[Category: Porin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:43:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:45:10 2008''

Revision as of 06:45, 28 July 2008

Image:1uun.png

Template:STRUCTURE 1uun

MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)

Template:ABSTRACT PUBMED 14976314

About this Structure

1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314

Page seeded by OCA on Mon Jul 28 09:45:10 2008

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