9hm7

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Current revision (10:25, 3 September 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hm7 is ON HOLD until Paper Publication
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==Cryo-EM structure of apo human separase with the mutation C2029S==
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<StructureSection load='9hm7' size='340' side='right'caption='[[9hm7]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors: Yu, J., Schmidt, S., Botto, M., Boland, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HM7 FirstGlance]. <br>
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Description: Cryo-EM structure of apo human separase with the mutation C2029S
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Botto, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hm7 OCA], [https://pdbe.org/9hm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hm7 RCSB], [https://www.ebi.ac.uk/pdbsum/9hm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hm7 ProSAT]</span></td></tr>
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[[Category: Boland, A]]
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</table>
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[[Category: Yu, J]]
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== Function ==
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[[Category: Schmidt, S]]
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[https://www.uniprot.org/uniprot/ESPL1_HUMAN ESPL1_HUMAN] Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.<ref>PMID:10411507</ref> <ref>PMID:11509732</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Boland A]]
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[[Category: Botto M]]
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[[Category: Schmidt S]]
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[[Category: Yu J]]

Current revision

Cryo-EM structure of apo human separase with the mutation C2029S

PDB ID 9hm7

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