9kxp

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Current revision (07:26, 8 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9kxp is ON HOLD until 2026-12-07
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==Crystal structure of the PIN1 and fragment 33 complex.==
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<StructureSection load='9kxp' size='340' side='right'caption='[[9kxp]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9kxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KXP FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EHB:(2,4-dimethyl-1,3-thiazol-5-yl)methanol'>A1EHB</scene>, <scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kxp OCA], [https://pdbe.org/9kxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kxp RCSB], [https://www.ebi.ac.uk/pdbsum/9kxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kxp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Qin WM]]
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[[Category: Shu HL]]
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[[Category: Wu TT]]
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[[Category: Xiao QJ]]

Current revision

Crystal structure of the PIN1 and fragment 33 complex.

PDB ID 9kxp

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OCA

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