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9l04

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Current revision (06:21, 25 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9l04 is ON HOLD until Paper Publication
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==Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK783==
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<StructureSection load='9l04' size='340' side='right'caption='[[9l04]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Sakai, N., Mishima-Tsumagari, C., Shirouzu, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9l04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L04 FirstGlance]. <br>
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Description: Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK783
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L4C:4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]pyrimidin-2-amine'>A1L4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Shirouzu, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l04 OCA], [https://pdbe.org/9l04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l04 RCSB], [https://www.ebi.ac.uk/pdbsum/9l04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l04 ProSAT]</span></td></tr>
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[[Category: Mishima-Tsumagari, C]]
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</table>
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[[Category: Sakai, N]]
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== Disease ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mishima-Tsumagari C]]
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[[Category: Sakai N]]
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[[Category: Shirouzu M]]

Current revision

Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK783

PDB ID 9l04

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