1uw6

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[[Image:1uw6.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1uw6| PDB=1uw6 | SCENE= }}
{{STRUCTURE_1uw6| PDB=1uw6 | SCENE= }}
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'''X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE'''
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===X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE===
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==Overview==
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Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABAA, GABAC, 5HT3 serotonin, and glycine receptors. Ligand binding is driven by enthalpy and is accompanied by conformational changes in the ligand binding site. Residues in the binding site contract around the ligand, with the largest movement in the C loop. As expected, the binding is characterized by substantial aromatic and hydrophobic contributions, but additionally there are close contacts between protein oxygens and positively charged groups in the ligands. The higher affinity of nicotine is due to a main chain hydrogen bond with the B loop and a closer packing of the aromatic groups. These structures will be useful tools for the development of new drugs involving nicotinic acetylcholine receptor-associated diseases.
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(as it appears on PubMed at http://www.pubmed.gov), where 15046723 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15046723}}
==About this Structure==
==About this Structure==
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[[Category: Nicotine]]
[[Category: Nicotine]]
[[Category: Pentamer]]
[[Category: Pentamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:45:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:40:37 2008''

Revision as of 11:40, 27 July 2008

Image:1uw6.png

Template:STRUCTURE 1uw6

X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE

Template:ABSTRACT PUBMED 15046723

About this Structure

1UW6 is a Single protein structure of sequence from Lymnaea stagnalis. Full crystallographic information is available from OCA.

Reference

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures., Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB, Sixma TK, Neuron. 2004 Mar 25;41(6):907-14. PMID:15046723

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