1uw5

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{{STRUCTURE_1uw5| PDB=1uw5 | SCENE= }}
{{STRUCTURE_1uw5| PDB=1uw5 | SCENE= }}
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'''STRUCTURE OF PITP-ALPHA COMPLEXED TO PHOSPHATIDYLINOSITOL'''
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===STRUCTURE OF PITP-ALPHA COMPLEXED TO PHOSPHATIDYLINOSITOL===
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==Overview==
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Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. In higher eukaryotes PITPalpha is required for cellular functions such as phospholipase C-mediated signaling, regulated exocytosis, and secretory vesicle formation. We have determined the crystal structure of human PITPalpha bound to its physiological ligand, PI, at 2.95 A resolution. The structure identifies the critical side chains within the lipid-headgroup binding pocket that define the exquisite specificity for PI. Mutational analysis of the PI binding pocket is in good agreement with the structural data and allows manipulation of functional properties of PITPalpha. Surprisingly, there are no major conformational differences between PI- and PC-loaded PITPalpha, despite previous predictions. In the crystal, PITPalpha-PI is dimeric, with two identical dimers in the asymmetric unit. The dimer interface masks precisely the sequence we identify as contributing to PITPalpha membrane interaction. Our structure represents a soluble, transport-competent form of PI-loaded PITPalpha.
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{{ABSTRACT_PUBMED_14962392}}
==About this Structure==
==About this Structure==
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[[Category: Transfer protein]]
[[Category: Transfer protein]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:45:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:05:50 2008''

Revision as of 06:05, 28 July 2008

Image:1uw5.png

Template:STRUCTURE 1uw5

STRUCTURE OF PITP-ALPHA COMPLEXED TO PHOSPHATIDYLINOSITOL

Template:ABSTRACT PUBMED 14962392

About this Structure

1UW5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol., Tilley SJ, Skippen A, Murray-Rust J, Swigart PM, Stewart A, Morgan CP, Cockcroft S, McDonald NQ, Structure. 2004 Feb;12(2):317-26. PMID:14962392

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