This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1uyu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1uyu.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1uyu.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1uyu| PDB=1uyu | SCENE= }}
{{STRUCTURE_1uyu| PDB=1uyu | SCENE= }}
-
'''XENON COMPLEX OF WILDTYPE P450CAM FROM PSEUDOMONAS PUTIDA'''
+
===XENON COMPLEX OF WILDTYPE P450CAM FROM PSEUDOMONAS PUTIDA===
-
==Overview==
+
<!--
-
In cytochrome P450s, the active site is situated deep inside the protein next to the heme cofactor, and is often completely isolated from the surrounding solvent. To identify routes by which substrates may enter into and products exit from the active site, random expulsion molecular dynamics simulations were performed for three cytochrome P450s: CYP101, CYP102A1 and CYP107A1 [J. Mol. Biol. 303 (2000) 797; Proc. Natl. Acad. Sci. USA 99 (2002) 5361]. Amongst the different pathways identified, one pathway was found to be common to all three cytochrome P450s although the mechanism of ligand passage along it was different in each case and apparently adapted to the substrate specificity of the enzyme. Recently, a number of new crystal structures of cytochrome P450s have been solved. Here, we analyse the open channels leading to the active site that these structures reveal. We find that in addition to showing the common pathway, they provide experimental evidence for the existence of three additional channels that were identified by simulation. We also discuss how the location of xenon binding sites in CYP101 suggests a role for one of the pathways identified by molecular dynamics simulations as a route for gaseous species, such as oxygen, to access the active site.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15219983}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15219983 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15219983}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Mono-oxygenase]]
[[Category: Mono-oxygenase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:52:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:17:50 2008''

Revision as of 13:17, 29 July 2008

Image:1uyu.png

Template:STRUCTURE 1uyu

XENON COMPLEX OF WILDTYPE P450CAM FROM PSEUDOMONAS PUTIDA

Template:ABSTRACT PUBMED 15219983

About this Structure

1UYU is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

A survey of active site access channels in cytochromes P450., Wade RC, Winn PJ, Schlichting I, Sudarko, J Inorg Biochem. 2004 Jul;98(7):1175-82. PMID:15219983

Page seeded by OCA on Tue Jul 29 16:17:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uyu"
Personal tools