9mn5

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Current revision (05:46, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9mn5 is ON HOLD until Paper Publication
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==Structure of the human mitochondrial open transcription initiation complex, IC0==
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<StructureSection load='9mn5' size='340' side='right'caption='[[9mn5]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9mn5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MN5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mn5 OCA], [https://pdbe.org/9mn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mn5 RCSB], [https://www.ebi.ac.uk/pdbsum/9mn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mn5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Herbine KH]]
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[[Category: Nayak AR]]
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[[Category: Temiakov D]]

Current revision

Structure of the human mitochondrial open transcription initiation complex, IC0

PDB ID 9mn5

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