9mn7

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Current revision (05:46, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9mn7 is ON HOLD until Paper Publication
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==Structure of the human mitochondrial late-stage transcription initiation complex, IC8==
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<StructureSection load='9mn7' size='340' side='right'caption='[[9mn7]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9mn7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MN7 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mn7 OCA], [https://pdbe.org/9mn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mn7 RCSB], [https://www.ebi.ac.uk/pdbsum/9mn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mn7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TFB2M_HUMAN TFB2M_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.<ref>PMID:12068295</ref> <ref>PMID:12897151</ref> <ref>PMID:15526033</ref> <ref>PMID:20410300</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Herbine KH]]
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[[Category: Nayak AR]]
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[[Category: Temiakov D]]

Current revision

Structure of the human mitochondrial late-stage transcription initiation complex, IC8

PDB ID 9mn7

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OCA

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