1uz8

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[[Image:1uz8.jpg|left|200px]]
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{{Seed}}
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[[Image:1uz8.png|left|200px]]
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{{STRUCTURE_1uz8| PDB=1uz8 | SCENE= }}
{{STRUCTURE_1uz8| PDB=1uz8 | SCENE= }}
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'''ANTI-LEWIS X FAB FRAGMENT IN COMPLEX WITH LEWIS X'''
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===ANTI-LEWIS X FAB FRAGMENT IN COMPLEX WITH LEWIS X===
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==Overview==
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The Lewis X trisaccharide is pivotal in mediating specific cell-cell interactions. Monoclonal antibody 291-2G3-A, which was generated from mice infected with schistosomes, has been shown to recognize the Lewis X trisaccharide. Here we describe the structure of the Fab fragment of 291-2G3-A, with Lewis X, to 1.8 A resolution. The crystallographic analysis revealed that the antigen binding site is a rather shallow binding pocket, and residues from all six complementary determining regions of the antibody contact all sugar residues. The high specificity of the binding pocket does not result in high affinity; the K(D) determined by isothermal calorimetry is 11 microM. However, this affinity is in the same range as for other sugar-antibody complexes. The detailed understanding of the antibody-Lewis X interaction revealed by the crystal structure may be helpful in the design of better diagnostic tools for schistosomiasis and for studying Lewis X-mediated cell-cell interactions by antibody interference.
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The line below this paragraph, {{ABSTRACT_PUBMED_15242599}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15242599 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15242599}}
==About this Structure==
==About this Structure==
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[[Category: Anti-carbohydrate]]
[[Category: Anti-carbohydrate]]
[[Category: Antibody]]
[[Category: Antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:53:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:29:15 2008''

Revision as of 00:29, 29 July 2008

Image:1uz8.png

Template:STRUCTURE 1uz8

ANTI-LEWIS X FAB FRAGMENT IN COMPLEX WITH LEWIS X

Template:ABSTRACT PUBMED 15242599

About this Structure

1UZ8 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of an anti-Lewis X Fab fragment in complex with its Lewis X antigen., van Roon AM, Pannu NS, de Vrind JP, van der Marel GA, van Boom JH, Hokke CH, Deelder AM, Abrahams JP, Structure. 2004 Jul;12(7):1227-36. PMID:15242599

Page seeded by OCA on Tue Jul 29 03:29:15 2008

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