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1uzg

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[[Image:1uzg.gif|left|200px]]
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{{Seed}}
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[[Image:1uzg.png|left|200px]]
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{{STRUCTURE_1uzg| PDB=1uzg | SCENE= }}
{{STRUCTURE_1uzg| PDB=1uzg | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN'''
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===CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN===
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==Overview==
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Dengue virus is an emerging global health threat. The major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. Antibodies that bind but fail to neutralize noncognate serotypes enhance infection. We have determined the crystal structure of a soluble fragment of the envelope glycoprotein E from dengue virus type 3. The structure closely resembles those of E proteins from dengue type 2 and tick-borne encephalitis viruses. Serotype-specific neutralization escape mutants in dengue virus E proteins are all located on a surface of domain III, which has been implicated in receptor binding. While antibodies against epitopes in domain I are nonneutralizing in dengue virus, there are neutralizing antibodies that recognize serotype-conserved epitopes in domain II. The mechanism of neutralization for these antibodies is probably inhibition of membrane fusion. Our structure shows that neighboring glycans on the viral surface are spaced widely enough (at least 32 A) that they can interact with multiple carbohydrate recognition domains on oligomeric lectins such as DC-SIGN, ensuring maximum affinity for these putative receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_15613349}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15613349 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15613349}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Virus/viral protein]]
[[Category: Virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:54:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:45:10 2008''

Revision as of 10:45, 29 July 2008

Image:1uzg.png

Template:STRUCTURE 1uzg

CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN

Template:ABSTRACT PUBMED 15613349

About this Structure

1UZG is a Single protein structure of sequence from Dengue virus 3. Full crystallographic information is available from OCA.

Reference

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:15613349

Page seeded by OCA on Tue Jul 29 13:45:10 2008

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