9i5w
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of mature Activin A from DMSO solvent optimisation of XChem fragment screen== | |
| - | + | <StructureSection load='9i5w' size='340' side='right'caption='[[9i5w]], [[Resolution|resolution]] 1.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9i5w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I5W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.774Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: Hyvonen | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i5w OCA], [https://pdbe.org/9i5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i5w RCSB], [https://www.ebi.ac.uk/pdbsum/9i5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i5w ProSAT]</span></td></tr> |
| - | [[Category: Quambusch | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/INHBA_HUMAN INHBA_HUMAN] Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hyvonen M]] | ||
| + | [[Category: Quambusch L]] | ||
Current revision
Structure of mature Activin A from DMSO solvent optimisation of XChem fragment screen
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