1ykb
From Proteopedia
(New page: 200px<br /> <applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ykb, resolution 2.60Å" /> '''Crystal Structure o...) |
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| - | [[Image:1ykb.gif|left|200px]]<br /> | + | [[Image:1ykb.gif|left|200px]]<br /><applet load="1ykb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ykb" size=" | + | |
caption="1ykb, resolution 2.60Å" /> | caption="1ykb, resolution 2.60Å" /> | ||
'''Crystal Structure of Insect Cell Expressed IL-22'''<br /> | '''Crystal Structure of Insect Cell Expressed IL-22'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of interleukin-22 expressed in Drosophila | + | The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition. |
==About this Structure== | ==About this Structure== | ||
| - | 1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Logsdon, N | + | [[Category: Logsdon, N J.]] |
| - | [[Category: Walter, M | + | [[Category: Walter, M R.]] |
[[Category: Xu, T.]] | [[Category: Xu, T.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: interleukin]] | [[Category: interleukin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:18 2008'' |
Revision as of 14:06, 21 February 2008
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Crystal Structure of Insect Cell Expressed IL-22
Overview
The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.
About this Structure
1YKB is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417
Page seeded by OCA on Thu Feb 21 16:06:18 2008
Categories: Homo sapiens | Single protein | Logsdon, N J. | Walter, M R. | Xu, T. | NAG | Cytokine | Glycosylation | Il-22 | Interleukin
