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1v1j

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[[Image:1v1j.gif|left|200px]]
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{{STRUCTURE_1v1j| PDB=1v1j | SCENE= }}
{{STRUCTURE_1v1j| PDB=1v1j | SCENE= }}
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'''CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO'''
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===CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO===
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==Overview==
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The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.
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(as it appears on PubMed at http://www.pubmed.gov), where 15162210 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15162210}}
==About this Structure==
==About this Structure==
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[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Shikimate]]
[[Category: Shikimate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:58:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:47:42 2008''

Revision as of 12:47, 28 July 2008

Image:1v1j.png

Template:STRUCTURE 1v1j

CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO

Template:ABSTRACT PUBMED 15162210

About this Structure

1V1J is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210

Page seeded by OCA on Mon Jul 28 15:47:42 2008

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