9li8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Bcl-xL in complex with HRK BH3 peptide== | |
| - | + | <StructureSection load='9li8' size='340' side='right'caption='[[9li8]], [[Resolution|resolution]] 2.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9li8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LI8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9li8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9li8 OCA], [https://pdbe.org/9li8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9li8 RCSB], [https://www.ebi.ac.uk/pdbsum/9li8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9li8 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Wang | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Guo M]] | ||
| + | [[Category: Wang J]] | ||
| + | [[Category: Wei H]] | ||
Current revision
Crystal structure of Bcl-xL in complex with HRK BH3 peptide
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Categories: Homo sapiens | Large Structures | Guo M | Wang J | Wei H
