1v6p

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[[Image:1v6p.jpg|left|200px]]
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{{STRUCTURE_1v6p| PDB=1v6p | SCENE= }}
{{STRUCTURE_1v6p| PDB=1v6p | SCENE= }}
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'''Crystal structure of Cobrotoxin'''
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===Crystal structure of Cobrotoxin===
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==Overview==
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By using single wavelength anomalous diffraction phasing based on the anomalous signal from copper atoms, the crystal structure of atratoxin was determined at the resolution of 1.5 A and was refined to an ultrahigh resolution of 0.87 A. The ultrahigh resolution electron density maps allowed the modeling of 38 amino acid residues in alternate conformations and the location of 322 of 870 possible hydrogen atoms. To get accurate information at the atomic level, atratoxin-b (an analog of atratoxin with reduced toxicity) was also refined to an atomic resolution of 0.92 A. By the sequence and structural comparison of these two atratoxins, Arg(33) and Arg(36) were identified to be critical to their varied toxicity. The effect of copper ions on the distribution of hydrogen atoms in atratoxin was discussed, and the interactions between copper ions and protein residues were analyzed based on a statistical method, revealing a novel pentahedral copper-binding motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 15252034 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15252034}}
==About this Structure==
==About this Structure==
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[[Category: Naja atra]]
[[Category: Naja atra]]
[[Category: Short-chain neurotoxin]]
[[Category: Short-chain neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:09:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:37:47 2008''

Revision as of 03:37, 28 July 2008

Image:1v6p.png

Template:STRUCTURE 1v6p

Crystal structure of Cobrotoxin

Template:ABSTRACT PUBMED 15252034

About this Structure

1V6P is a Single protein structure of sequence from Naja atra. Full crystallographic information is available from OCA.

Reference

The atomic resolution crystal structure of atratoxin determined by single wavelength anomalous diffraction phasing., Lou X, Liu Q, Tu X, Wang J, Teng M, Niu L, Schuller DJ, Huang Q, Hao Q, J Biol Chem. 2004 Sep 10;279(37):39094-104. Epub 2004 Jul 12. PMID:15252034

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