2cpo
From Proteopedia
(New page: 200px<br /> <applet load="2cpo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cpo, resolution 2.1Å" /> '''CHLOROPEROXIDASE'''<...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CPO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Leptoxyphium_fumago Leptoxyphium fumago]] with NAG, MAN, MN and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CPO OCA]]. | + | 2CPO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Leptoxyphium_fumago Leptoxyphium fumago]] with NAG, MAN, MN and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10]]. Structure known Active Sites: HE1, HEM, MN, NG1, NG2, NG3, OG1, OG2, OG3, OG4, OG5, OG6, OG7 and OG8. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CPO OCA]]. |
==Reference== | ==Reference== | ||
The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid., Sundaramoorthy M, Terner J, Poulos TL, Structure. 1995 Dec 15;3(12):1367-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8747463 8747463] | The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid., Sundaramoorthy M, Terner J, Poulos TL, Structure. 1995 Dec 15;3(12):1367-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8747463 8747463] | ||
| + | [[Category: Chloride peroxidase]] | ||
[[Category: Leptoxyphium fumago]] | [[Category: Leptoxyphium fumago]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: heme peroxidase]] | [[Category: heme peroxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:59:33 2007'' |
Revision as of 09:54, 30 October 2007
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CHLOROPEROXIDASE
Overview
BACKGROUND: Chloroperoxidase (CPO) is a versatile heme-containing enzyme, that exhibits peroxidase, catalase and cytochrome P450-like activities in, addition to catalyzing halogenation reactions. The structure determination, of CPO was undertaken to help elucidate those structural features that, enable the enzyme to exhibit these multiple activities. RESULTS: Despite, functional similarities with other heme enzymes, CPO folds into a novel, tertiary structure dominated by eight helical segments. The catalytic, base, required to cleave the peroxide O-O bond, is glutamic acid rather, than histidine as in other peroxidases. CPO contains a hydrophobic patch, above the heme that could be the binding site for substrates that undergo, P450-like reactions. The crystal structure also shows ... [(full description)]
About this Structure
2CPO is a [Single protein] structure of sequence from [Leptoxyphium fumago] with NAG, MAN, MN and HEM as [ligands]. Active as [Chloride peroxidase], with EC number [1.11.1.10]. Structure known Active Sites: HE1, HEM, MN, NG1, NG2, NG3, OG1, OG2, OG3, OG4, OG5, OG6, OG7 and OG8. Full crystallographic information is available from [OCA].
Reference
The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid., Sundaramoorthy M, Terner J, Poulos TL, Structure. 1995 Dec 15;3(12):1367-77. PMID:8747463
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