1va2

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[[Image:1va2.gif|left|200px]]
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{{STRUCTURE_1va2| PDB=1va2 | SCENE= }}
{{STRUCTURE_1va2| PDB=1va2 | SCENE= }}
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'''Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 2)'''
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===Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 2)===
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==Overview==
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To understand the DNA recognition mechanism of zinc finger motifs of transcription factor Sp1, we have determined the solution structure of DNA-binding domain of the Sp1 by solution NMR techniques. The DNA-binding domain of Sp1 consists of three Cys(2)His(2)-type zinc finger motifs. They have typical betabetaalpha zinc finger folds and relatively random orientations. From DNA-binding analysis performed by NMR and comparison between structures determined here and previously reported structures of other zinc fingers, it was assumed that DNA recognition modes of fingers 2 and 3 would be similar to those of fingers of Zif268, in which each finger recognizes four base pairs strictly by using residues at positions -1, 2, 3, and 6 of the recognition helix. On the contrary, finger 1 can use only two residues for DNA recognition, Lys550 and His553 at positions -1 and 3 of the helix, and has more relaxed sequence and site specificity than other Cys(2)His(2) zinc fingers. It is proposed that this relaxed property of finger 1 allows transcription factor Sp1 to bind various DNA sequences with high affinity.
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{{ABSTRACT_PUBMED_15609997}}
==About this Structure==
==About this Structure==
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1VA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VA2 OCA].
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1VA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VA2 OCA].
==Reference==
==Reference==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:17:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:47:32 2008''

Revision as of 19:47, 27 July 2008

Image:1va2.png

Template:STRUCTURE 1va2

Solution Structure of Transcription Factor Sp1 DNA Binding Domain (Zinc Finger 2)

Template:ABSTRACT PUBMED 15609997

About this Structure

1VA2 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of transcription factor Sp1 DNA binding domain., Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y, Biochemistry. 2004 Dec 28;43(51):16027-35. PMID:15609997

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